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KMID : 0921620110410040213
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Journal of Bacteriology and Virology
2011 Volume.41 No. 4 p.213 ~ p.223
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Herpesviral Interaction with Autophagy
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Liang Chengyu
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Abstract
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Autophagy constitutes a major catabolic hub for the quality control of intracellular entities of eukaryotic cells, and is emerging as an essential part of the host antiviral defense mechanism. However, in turn, viruses have evolved elegant strategies to co-opt various stages of the cellular autophagy pathway to establish virulence in vivo. This is particularly the case in the ubiquitous and persistent herpesvirus infection. In this review, I will focus on recent findings regarding the crosstalk between the herpes virus family and the autophagy pathway, with a look at the molecular mechanisms they use to disturb cells' autophagy regulation and eventually result in persistence and pathogenesis.
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KEYWORD
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Herpesviral Interaction with Autophagy
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